Naringin regulates the cGAS-STING pathway to improve mitochondrial dysfunction and ferroptosis after myocardial ischemia-reperfusion injury. (PubMed, Cytotechnology) - May 19, 2025 - "Nar significantly reduced myocardial cell injury by improving mitochondrial function and decreasing oxidative stress, particularly the stress induced by a ferroptosis activator (Erastin). Additionally, the in vivo MI/R rat model further confirmed that Nar inhibited the activation of the cGAS-STING pathway, thereby attenuating myocardial injury. Collectively, Nar exerts protective effects against MI/RI by regulating mitochondrial dysfunction and ferroptosis, primarily through inhibition of the cGAS-STING pathway."
Journal • Cardiovascular • Metabolic Disorders • Myocardial Infarction • Myocardial Ischemia • Reperfusion Injury
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Junjie He; Xinwei Zhang; Yanna Yang; Zhen Xu
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