FERROPTOSIS: AN IRON-EXPLOITING STRATEGY TO TARGET ACUTE LYMPHOBLASTIC LEUKEMIA (FIEST-ALL) (EHA 2025) - May 16, 2025 - Abstract #PF354; Pres time: Jun 13, 2025; 06:30 PM - 07:30 PM; Location: Poster Hall; "Drugs used included RSL3, APR-246, Erastin, and MI-463 (Cayman Chemicals). In conclusion, the results obtained on cell lines and primary samples indicate a novel combinatorial therapeutic approach for KMT2A-r patients, suggesting that the current targeted therapy can prime the cells to expose additional metabolic vulnerabilities."
Acute Lymphocytic Leukemia • B Acute Lymphoblastic Leukemia • Hematological Malignancies • Leukemia • Oncology • Solid Tumor • T Acute Lymphoblastic Leukemia • KMT2A
|
|
Martina Maria Capelletti; Martina Failla; Grazia Fazio; Jolanda Sarno; Michela Bardini; Luigia Valsecchi; Sara Pelucchi; Giovanni Cazzaniga; Angela Maria Savino
|