Melatonin Inhibiting Neuronal Cells Ferroptosis Through Lipid Metabolic Reprogramming. (PubMed, Mol Neurobiol) - May 14, 2025 - "Firstly, the inhibitory effect of melatonin on ferroptosis was verified by treating HT22 cells with melatonin, Erastin, and Ferrostatin-1...However, melatonin can reduce the protein levels of Trib3 and Atf4, increase the survival rate of HT-22 cells and the activity of GPX4, and reduce the ROS content. Melatonin inhibits neuronal ferroptosis by affecting the Atf4/Trib3 axis via the modulation of lipid metabolism."
Journal • Metabolic Disorders • ATF4 • GPX4 • TRIB3
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Chenhui Zhou; Fanyong Gong; Haifeng Wang; Jianyong Wang; Wenhui Zhao; Yi Huang
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