Regulation of SLC7A11 by LncRNA GPRC5D-AS1 mediates ferroptosis in skeletal muscle: Mechanistic exploration of sarcopenia. (PubMed, Front Mol Biosci) - May 1, 2025 - "A ferroptosis model was established in human skeletal muscle cells (HSKM) using the inducer erastin, and GPRC5D-AS1 overexpression plasmids were introduced to observe their effects on cell proliferation and ferroptosis indicators...Conversely, silencing SLC7A11 diminished the protective effects of GPRC5D-AS1 on cell proliferation and ferroptosis. These findings suggest that GPRC5D-AS1 overexpression increases SLC7A11 expression and reduces ferroptosis incidence in HSKM."
Journal • Sarcopenia • ACSL4 • GPRC5D • GPX4 • MT-CO2 • PACERR • PTGS2 • SLC7A11
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Jie Li; Qun Li; Wei Gong; Yan Wang; Yating Gao
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