Targeting HCG18 counteracts ferroptosis resistance via blocking the miR-30a-5p/RRM2/GSS pathway in hepatocellular carcinoma. (PubMed, Int J Biol Sci) - Apr 30, 2025 - "The colony formation assay demonstrated that overexpression of HCG18 inhibited erastin-induced cell death. In addition, in vivo experiments have also confirmed that HCG18 can inhibit ferroptosis by regulating the expression of RRM2, thereby promoting HCC proliferation. Our study discovered a novel lncRNA HCG18, as a "switch-like" molecule of the axis of miR-30a-5p/RRM2/GSS, confers resistance to ferroptosis and holds promise as a potential target for ferroptosis-dependent therapy."
Journal • Hepatocellular Cancer • Oncology • Solid Tumor • MIR30A • RRM2
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Chen Lu; Heng Jia; Jianping Zhang; Jie Li; Ming Jin; Shuoke Duan; Sizheng Sun; Tian Zhan; Xinru Du; Yawei Liu; Yuan Li
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