Hsa_circ_0001944 Regulates FXR/TLR4 Pathway and Ferroptosis to Alleviate Nickel Oxide Nanoparticles-Induced Collagen Formation in LX-2 Cells. (PubMed, Toxics) - Apr 27, 2025 - "To investigate the regulatory relationship among FXR, TLR4 and ferroptosis, we treated LX-2 cells with FXR agonist (GW4064), TLR4 inhibitor (TAK-242) and ferroptosis agonist (Erastin) combined with NiONPs. Overexpression of hsa_circ_0001944 increased FXR level, reduced TLR4 level, increased the ferroptosis features and alleviated collagen deposition in LX-2 cells. In summary, we demonstrated that hsa_circ_0001944 regulates the FXR/TLR4 pathway and ferroptosis alleviate collagen formation induced by NiONPs."
IO biomarker • Journal • Fibrosis • Hepatology • Immunology • Liver Cirrhosis
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Gege Li; Haodong Zhou; Hui Wang; Jiarong Tang; Lijiao Ma; Qingyang Chen; Sheng Li; Xi Kang; Xuhong Chang; Yingbiao Sun
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