Inhibition of LPL suppresses the osteoclast differentiation of bone-marrow-derived macrophages by promoting the ACSL4 ubiquitination. (PubMed, Int Immunopharmacol) - Apr 27, 2025 - "Suppression of LPL inhibits the osteoclast differentiation of BMMs in vitro. The mechanism may be related to the LPL knockdown induced USP14 meidated the ACSL4 ubiquitination. Taken together, down-regulation of LPL may be a promising method to suppress osteoclast differentiation to treat osteoporosis."
Journal • Osteoporosis • Rheumatology • Targeted Protein Degradation • ACSL4 • CSF1 • CTSK • LPL • USP14
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Dong Hu; Li Zhang; Shaoyan Shi; Sibo Wang; Yansheng Huang
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