ETV4/ALYREF-mediated glycolytic metabolism through PKM2 enhances resistance to ferroptosis and promotes the development of intrahepatic cholangiocarcinoma. (PubMed, Cancer Metab) - Apr 27, 2025 - "ETV4 promotes ICC development and ferroptosis resistance by facilitating glycolytic metabolism, and regulating PKM2 transcription by directly binding to the PKM2 promoter. Additionally, it mediates m5C-dependent PKM2 stabilization by directly binding to ALYREF. This study identified a new potential therapeutic target for ICC."
Journal • Biliary Cancer • Cholangiocarcinoma • Hepatocellular Cancer • Hepatology • Liver Cancer • Oncology • Solid Tumor • ALYREF • ETV4 • PKM
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Changjun Liu; Haoquan Wen; Wenbin Duan; Xianhai Mao; Xiaohui Wang; Zhongzhi Ma
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