Ferroptosis as a therapeutic vulnerability in MDM2 inhibition in dedifferentiated liposarcoma. (PubMed, Oncol Lett) - Apr 18, 2025 - "Nutlin-3 combined with erastin or RSL3 reduced absolute p-4EBP-1 levels in NDDLS-1 cells and p-p70S6 levels in both cell lines, with no significant impact on the p-4EBP-1/4EBP-1 and p-p70S6/p70S6 ratios. These results indicate that ferroptosis is a therapeutic vulnerability in the response to MDM2 inhibition in DDLPS. Furthermore, combining MDM2 inhibitors with ferroptosis-inducing agents may provide a potential therapeutic strategy for DDLPS and the role of mTOR in the pro-apoptotic effect of these combinations deserve further investigation."
Journal • Liposarcoma • Oncology • Sarcoma • Solid Tumor • GPX4 • SLC3A2 • SLC7A11
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Chao-Ming Chen; Chiao-Han Yen; Chueh-Chuan Yen; Jir-You Wang; Jonathan A Fletcher; Muh-Hwa Yang; Paul Chih-Hsueh Chen; Po-Kuei Wu; San-Chi Chen; Ta-Chung Chao; Wen-Chi Wu; Yung-Chan Lin
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