Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation. (PubMed, Nat Chem Biol) - Apr 18, 2025 - "A synthetic Galectin-13 mimetic peptide was shown to strongly enhance the sensitivity of tumors to the imidazole ketone erastin, radiotherapy and immunotherapy by boosting ferroptosis. In particular, cancer stem cells were vulnerable to the combination of Galectin-13 mimetic peptide and ferroptosis inducers. Our study provides new insights into ferroptosis propagation and highlights novel strategies for targeting ferroptosis to treat tumors."
IO biomarker • Journal • Oncology • LGALS1 • PRKCB • SLC7A11
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Bing-Xin Hu; Gong-Kan Feng; Hai-Liang Zhang; Hui-Qi Shen; Li-Chao Li; Rong Deng; Shan Liu; Xiao-Feng Zhu; Yi-Qing Guo; Yu-Hong Chen; Zhi-Ling Li; Zhi-Peng Ye
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