Nicotinamide mononucleotide mitigates hyperoxia-aggravated septic lung injury via the GPx4-mediated anti-ferroptosis signaling pathway in alveolar epithelial cells.

erastin - Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Columbia University, Prolexys

Nicotinamide mononucleotide mitigates hyperoxia-aggravated septic lung injury via the GPx4-mediated anti-ferroptosis signaling pathway in alveolar epithelial cells. (PubMed, Free Radic Biol Med) - Apr 18, 2025 - "Hyperoxia aggravates septic lung injury by inducing ferroptosis of AECs. NMN can mitigate hyperoxia-aggravated septic lung injury by up-regulating GPx4 through increasing SIRT6 and inhibiting ferroptosis of AECs."
Journal • Infectious Disease • Inflammation • Respiratory Diseases • Septic Shock • ACSL4 • GPX4 • IL6 • SIRT6

http://www.ncbi.nlm.nih.gov/pubmed/40246251

Fen Liu; Kejian Qian; Ning Zhao; Wenqiang Tao; Xinyi Yang; Xiufang Ouyang; Zhijian Sun

Apr 18, 2025