Targeting LINC00707 by vitamin D3 attenuates nitrogen mustard-caused dermal toxicity through inhibiting ferroptosis. (PubMed, Redox Biol) - Apr 18, 2025 - "Nitrogen mustard (NM) causes severe skin injury that is lack of effective and targeted therapies. The protective effects of VD3 against NM-caused dermal toxicity were blocked by erastin (a ferroptosis inducer), Nrf2 siRNA, LINC00707 overexpression and were enhanced by LINC00707 knockdown and Fer-1 in vitro and in vivo. In conclusion, VD3 ameliorated NM-caused dermal toxicity by inhibiting ferroptosis, which was partially mediated through the LINC00707-AKT1-GSK3β-Nrf2 signaling pathway."
Journal • GPX4 • LINC00707 • SLC7A11
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Feng Ye; Guorong Dan; He Tang; Jie Wu; Jiqing Zhao; Mingliang Chen; Xiaofeng Hu; Xiaogang Wang; Xiaolu Lu; Xunhu Dong; Yan Sai; Ying He; Yuanpeng Zhao; Zhongmin Zou
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