Defective Autophagy Drives Ferroptosis via Mitochondrial ROS in Diabetic Kidney Disease. (ERA 2025) - Apr 15, 2025 - Abstract #736; Pres time: Jun 5, 2025; 03:24 PM - 03:30 PM; Location: Focussed Oral Room 8; "In addition, rapamycin-mediated improvement of autophagy in db/db mice suppressed IR-induced AKI, demonstrating that improved autophagy attenuates ferroptosis in DKD. Using primary PTECs isolated from Atg5 knockout (Atg5KO) mice, ferroptotic cell death and lipid peroxidation were augmented in Atg5KO cells under erastin (a ferroptosis inducer) treatment... Defective autophagy enhances susceptibility to ferroptosis in DKD by promoting mitochondrial ROS generation. These findings suggest that therapeutic strategies aimed at improving autophagy may mitigate ferroptosis-related injury in DKD."
Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Diabetic Nephropathy • Metabolic Disorders • Nephrology • Oncology • Renal Disease • Reperfusion Injury • Type 1 Diabetes Mellitus • Type 2 Diabetes Mellitus • ATG5
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Sho Matsui1; Takeshi Yamamoto1; Yoshitaka Isaka1
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