Teneligliptin alleviates acute kidney injury by exerting anti-ferroptotic effects on renal tubules (ERA 2025) - Apr 15, 2025 - Abstract #2099; Pres time: Jun 5, 2025; 08:27 AM - 08:33 AM; Location: Focussed Oral Room 10; "Additionally, our previous research suggests that DPP-4 inhibitors may reduce cisplatin-induced AKI in humans [4]. Our study demonstrates that the DPP-4 inhibitor TG provides renoprotective effects against folic acid- and rhabdomyolysis-induced AKI by inhibiting ferroptosis in renal tubular cells. The findings suggest that TG reduces tubular cell death by specifically targeting ferroptotic pathways, as evidenced by its effectiveness in suppressing erastin-induced cell death and the lack of effect from apoptosis and necroptosis inhibitors. These results highlight the potential of TG as a therapeutic option for AKI by modulating ferroptosis-related mechanisms."
Acute Kidney Injury • Colon Cancer • Colorectal Cancer • Nephrology • Oncology • Renal Disease • Solid Tumor • MB
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Chiemi Ema1; Takamasa Iwakura1; Kuuya Okazaki1; Hideo Yasuda1
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