The PERK-eIF2α-ATF4 Axis Is Involved in Mediating ER-Stress-Induced Ferroptosis via DDIT4-mTORC1 Inhibition and Acetaminophen-Induced Hepatotoxicity. (PubMed, Antioxidants (Basel)) - Apr 14, 2025 - "Our findings reveal that the inhibition of eIF2α-ATF4 or ferroptosis protects against APAP-induced liver damage, underscoring the therapeutic potential of targeting these pathways. Overall, this study not only clarifies the intricate role of the PERK-eIF2α-ATF4 axis in ER-stress-and erastin-induced ferroptosis but also extends these findings to a clinically relevant model, providing a foundation for potential therapeutic interventions in conditions characterized by dysregulated ferroptosis and ER stress."
Journal • Hepatology • ATF4 • DDIT4
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Fedho Kusuma; Hun Taeg Chung; Jaeseok Han; Jeongmin Park; Kim Anh Nguyen; Soyoung Park; Thu-Hang Thi Nghiem; Yeonsoo Joe
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