Porphyromonas gingivalis-OMVs promote the epithelial-mesenchymal transition of oral squamous cell carcinoma by inhibiting ferroptosis through the NF-κB pathway.

erastin - Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Columbia University, Prolexys

Porphyromonas gingivalis-OMVs promote the epithelial-mesenchymal transition of oral squamous cell carcinoma by inhibiting ferroptosis through the NF-κB pathway. (PubMed, J Oral Microbiol) - Apr 10, 2025 - "In addition, P. g-OMVs promote the EMT of OSCC cells, which can be attenuated by ferroptosis activator erastin...P. g-OMVs promote OSCC progression by modulating the ferroptosis-related EMT through NF-κB signaling."
Journal • Oncology • Oral Cancer • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

http://www.ncbi.nlm.nih.gov/pubmed/40206095

Hang Si; Li Yu; Tiejun Zhou; Xiaoyan Zhang; Xinyue Liao; Yan Feng; YongXian Lai; Yun Feng

Apr 10, 2025