An active ingredient from the combination of Corydalis Rhizoma and Paeoniae Radix Alba relieves chronic compression injury-induced pain in rats by ameliorating AR/Mboat2-mediated ferroptosis in spinal cord neurons.

erastin - Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Columbia University, Prolexys

An active ingredient from the combination of Corydalis Rhizoma and Paeoniae Radix Alba relieves chronic compression injury-induced pain in rats by ameliorating AR/Mboat2-mediated ferroptosis in spinal cord neurons. (PubMed, Front Pharmacol) - Apr 9, 2025 - "Results in PC12 cells in vitro showed that YB60 reversed the downregulation of AR and Mboat2, and ameliorated ferroptosis induced by Erastin, while knockdown of AR eliminated the above effects of YB60. These findings indicated that YB60 exerted its analgesic effect by inhibiting ferroptosis in spinal cord neurons via modulation of the AR/Mboat2 pathway."
Journal • Preclinical • Inflammation • Pain • AR

http://www.ncbi.nlm.nih.gov/pubmed/40201699

Gui-Yang Xia; Jin-Yu Li; Lin-Nan Zhou; Sheng Lin; Xiao-Hong Wei; Ze-Ming Wang

Apr 9, 2025