SCD1 Inhibition Blocks the AKT-NRF2-SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma. (PubMed, Cancer Res) - Apr 9, 2025 - "SCD1 inhibition caused appreciable tumor regression in xenografts and augmented the efficacy of the ferroptosis inducer erastin. Overall, this study provides insights into the role of the SCD1-SLC7A11 axis in regulating metabolic programming and predicting poor patient outcomes in a genetically defined subset of KRASmut-LUAD."
Journal • Lung Adenocarcinoma • Lung Cancer • Metabolic Disorders • Non Small Cell Lung Cancer • Oncology • Solid Tumor • KEAP1 • KRAS • SCD • SLC7A11 • STK11
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Andrew Elliott; Ari M VanderWalde; Balazs Halmos; Charles Coleman; Dan Hasson; Deniz Demircioglu; Elisa de Stanchina; Mirela Berisa; Nishant Gandhi; Omar Hayatt; Patrick C Ma; Triparna Sen; Utsav Sen; Vrinda Jethalia
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