IDO1-mediated AhR activation up-regulates pentose phosphate pathway via NRF2 to inhibit ferroptosis in lung cancer. (PubMed, Biochem Pharmacol) - Apr 1, 2025 - "Moreover, combined treatment with IDO1 inhibitor and Erastin inhibited tumor growth, down-regulated SLC7A11 expression and PPP activity, promoted tumor ferroptosis in lung cancer-bearing mice. In conclusion, this study revealed the function of IDO1 in lung cancer ferroptosis and provided a new strategy for lung cancer therapy."
IO biomarker • Journal • Lung Cancer • Oncology • Solid Tumor • IDO1 • NFE2L2 • SLC7A11
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Fangzhou Meng; Jiani Zhan; Lili Yang; Qing Yang; Xiaoyang Qian; Xuewen Li; Yijia Chen; Yunqiu Chen; Yuying Liu; Zhenning He; Zhiyao Li
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