Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species. (PubMed, Adv Sci (Weinh)) - Apr 1, 2025 - "Ferroptosis inducers such as Erastin and RSL3 accelerate senescence; while, inhibitors such as liproxstatin-1 (Lip-1) and ferrostatin-1 (Fer-1) effectively mitigate both chemically and replicatively induced senescence. Notably, long-term Fer-1 treatment (over 6 months) does not adversely affect body weight or induce aging-related tissue damage but rejuvenates hematological parameters. These findings establish ferroptosis as a critical player in aging dynamics and highlight its inhibition as a promising strategy to extend healthspan and lifespan, providing valuable insights for translational approaches to combat aging and age-related decline."
Journal • Hematological Disorders • ANXA2 • FER • GPX4
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An-Guo Wu; Da-Lian Qin; Fei-Hong Huang; Hai-Jun Fu; Hui Cai; Jian-Ming Wu; Jiang-Min Zhou; Long Wang; Lu Yu; Qan Qiao; Qiao-Zhi Wang; Shi-Ying Li; Xiao-Gang Zhou; Xing-Yue Zhou; Ya-Ping Li; Yun-Fei Zhu
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