Targeting cTRIP12 counteracts ferroptosis resistance and augments sensitivity to immunotherapy in pancreatic cancer. (PubMed, Drug Resist Updat) - Mar 29, 2025 - "We elucidated the molecular mechanisms underlying the simultaneous occurrence of ferroptosis resistance and immune suppression in PDAC patients. Our study provides a novel therapeutic strategy that could promote ferroptosis in tumour cells and increase immunotherapy efficacy."
IO biomarker • Journal • Hepatology • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor • OGT • PD-L1 • PERK • TRIP12
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Chengke Xie; Chengyu Liao; Ge Li; Hongyi Lin; Jianfei Hu; Jinpeng Lu; Qiaowei Li; Shi Chen; Shuncang Zhu; Xiaoxiao Huang; Xinquan Lin; Yifeng Tian; Yinhao Chen; Yongding Wu; Zhiyuan Li; Zuwei Wang
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