Apelin-13 Protects Against Myocardial Hypoxia/Reoxygenation (H/R) Injury by Inhibiting Ferroptosis Via Nrf2 Activation. (PubMed, J Biochem Mol Toxicol) - Mar 28, 2025 - "These protective actions were negated by the ferroptosis inducer Erastin...Conversely, Nrf2 knockdown nullified the protective effects of Apelin-13 against ferroptosis and cardiomyocyte injury, underscoring the critical involvement of Nrf2 in mediating these benefits. Collectively, our results highlight the promising therapeutic potential of Apelin-13 in managing CAD."
Journal • Cardiovascular • Coronary Artery Disease • Metabolic Disorders • Reperfusion Injury • FTH1 • GPX4 • HMOX1 • TNNI3
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Chen Li; Fan Liang; Yanbo Sui; Yumiao Liu
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