Jingtian granule alleviates adenine-induced renal fibrosis in mice through SIRT3-Mediated deacetylation of P53. (PubMed, Front Pharmacol) - Mar 27, 2025 - "In addition, human proximal tubule epithelial cells (HK - 2) were treated with Erastin to induce ferroptosis, followed by exposure to JT...SIRT3 is the key ferroptosis - related mRNA regulated by JT. The ability of JT to modulate the SIRT3/P53 signaling pathway may be a viable approach for the treatment of renal interstitial fibrosis."
Journal • Preclinical • Chronic Kidney Disease • Fibrosis • Immunology • Nephrology • Renal Disease • GPX4 • SIRT3 • SLC7A11
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Chengyin Li; Huanbo Cheng; Linqun Wang; Rui Wang; Wei Zhao; Weinan Li; Xiaoyun Zhu; Xinyu Hu; YinFeng Shen; Yuanming Ba; Zhili Xiong
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