Tick HRF-dependent ferroptosis pathway to promote tick acquisition of Babesia microti. (PubMed, Front Cell Infect Microbiol) - Mar 27, 2025 - "In vivo studies demonstrated that the ferroptosis promoter Erastin increased B. microti load (p<0.05), while the inhibitor Ferrostatin-1 effectively decreased load (p<0.01)...Meanwhile, interference with tick HRF molecules showed increased divalent iron and ROS and decreased mitochondrial ridges compared with controls. These findings highlight the critical role of tick HRF molecules in regulating ferroptosis and acquisition of B. microti, thereby providing important insights for a deeper understanding of the tick-Babesia interaction."
Journal • Infectious Disease • GPX4
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Houshuang Zhang; Jie Cao; Jinlin Zhou; Shanming Hu; Songqin Chen; Yanan Wang; Yongzhi Zhou
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