Influence of a Very High-Molecular Weight Fucoidan from Laminaria hyperborea on Age-Related Macular Degeneration-Relevant Pathomechanisms in Ocular Cell Models. (PubMed, Mar Drugs) - Mar 26, 2025 - "Cell viability was tested with tetrazolium assay (MTT), oxidative stress was induced by H2O2 or erastin, respectively...Very high-molecular weight fucoidan from LH shows bioactivities against AMD-related pathological pathways, but adverse effects on RPE function may limit its suitability as a therapeutic compound. Smaller high-molecular weight fucoidans are recommended for further research."
Journal • Age-related Macular Degeneration • Eye Cancer • Macular Degeneration • Melanoma • Ocular Inflammation • Oncology • Ophthalmology • Retinal Disorders • Solid Tumor • Uveal Melanoma • CD59 • CXCL8 • IL6
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Alexa Klettner; Charlotte Seeba; Georg Kopplin; Johann Roider; Philipp Dörschmann; Sadia Fida Ullah; Tabea Thalenhorst; Vaibhav Srivastava
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