USP5 Suppresses Ferroptosis in Bladder Cancer Through Stabilization of GPX4. (PubMed, Curr Issues Mol Biol) - Mar 26, 2025 - "The addition of erastin significantly increased the viability and proliferation of T24 USP5-/- cells and significantly increased their ROS and MDA contents...Further studies showed that USP5 interacts with GPX4 and stabilizes GPX4 by inhibiting its ubiquitination These findings revealed USP5 inhibits ferroptosis in bladder cancer cells by stabilizing GPX4. The relationship between USP5 and ferroptosis could be a potential therapeutic target for bladder cancer."
Journal • Bladder Cancer • Genito-urinary Cancer • Oncology • Solid Tumor • Targeted Protein Degradation • GPX4 • USP5
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Caiying Liu; Huihui Zhang; Liang Huang; Xia Zhang; Xinrui Nie; Yanong Deng; Yuxuan Jiang
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