Physiologic regulation of lipid oxidation and ferroptosis by vitamin E, high-density lipoprotein and scavenger receptor class B type 1 (AACR 2025) - Mar 26, 2025 - Abstract #2824; Pres time: Apr 28, 2025; 02:00 PM - 05:00 PM; Location: Section 13; Poster Board No: 9; "Ferroptosis was induced using ML210 and erastin. We reveal a tunable cellular redox axis whereby HDLs containing α-toc target SR-B1 to reduce PL-OOH and prevent ferroptosis. Accordingly, this work reveals that the α-toc / HDL/ SR-B1 axis of ferroptosis prevention must be accounted for when targeting ferroptosis in vivo."
B Cell Lymphoma • Clear Cell Renal Cell Carcinoma • Diffuse Large B Cell Lymphoma • Genito-urinary Cancer • Hematological Malignancies • Lymphoma • Non-Hodgkin's Lymphoma • Oncology • Solid Tumor • APOB • GPX4
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Jonathan S. Rink; Andrea E. Calvert; Adam Y. Lin; SonBihn T. Nguyen; Leo I. Gordon; C Shad Thaxton
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