Mechanisms of BPM31510-induced cell death in cancer: lipid peroxidation and apoptosis pathways (AACR 2025) - Mar 26, 2025 - Abstract #1591; Pres time: Apr 28, 2025; 09:00 AM - 12:00 PM; Location: Section 16; Poster Board No: 7; "Cells were treated with BPM31510 and Erastin (a ferroptosis inducer) for 3 hours, and fluorescence intensity was measured to assess lipid peroxidation levels. Our findings demonstrate that BPM31510 differentially induces lipid peroxidation in cancer cells through a mechanism independent of ferroptosis, instead activating apoptosis as the primary pathway of cell death. The ferroptosis-independent cytotoxicity of BPM31510, combined with its selective targeting of cancer cells, highlights its potential as a unique therapeutic agent in glioblastoma."
Brain Cancer • CNS Tumor • Glioblastoma • Oncology • Solid Tumor • ANXA5
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Abbas Khojasteh; Michael A. Kiebish; Lisa Ghiglieri; Sylwia Stopka; Juan J. A. Aristizabal-Henao; Seema Nagpal; Maria-D Nastke; Stephane Gesta; Niven R. Narain; Vijay Modur; Lawrence Recht
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