Protein-Interference-Free and Kidney-Targeting NIR Fluorophores for Accurate in Vivo Imaging of H2S2 during Kidney Ferroptosis. (PubMed, Adv Healthc Mater) - Mar 24, 2025 - "Additionally, it successfully achieves real-time in vivo NIR fluorescence imaging of H2S2 during erastin/cisplatin induced renal ferroptosis. Moreover, it also enables rapid detection of H2S2 through in vitro optical urinalysis, offering significant diagnostic value for renal ferroptosis. Overall, this study not only presents a practical kidney-targeting H2S2 fluorescent probe NA-H2S2 with increased imaging accuracy but also provides promising kidney-targeting and albumin-insensitive aza-hemicyanine dyes for further development of kidney disease-related probes."
Journal • Preclinical • Nephrology • Renal Disease
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Dongxue Lu; Hua Chen; Jing Wang; Jingting Huang; Jinyuan Xu; Xiaoshan Chen; Xing-Can Shen; Zhangkang Lv
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