Biejiajian Pill Regulates Ferroptosis in Hepatocellular Carcinoma Cells via p62/Keap1/NRF2 Signaling Pathway: A Mechanism Study (PubMed, Sichuan Da Xue Xue Bao Yi Xue Ban) - Mar 20, 2025 - "Compared with the control group, the BJJP drug serum group, the erastin group, and the BJJP drug serum + erastin group showed increased iron content, decreased GSH content, increased MDA levels, increased ROS aggregation, decreased FTH1, GPX4, xCT, SLC40A1, p62, and NRF2 contents, increased Keap1 content, and decreased mitochondrial membrane potential (P < 0.05). BJJP regulates ferroptosis in Huh7 HCC cells by inhibiting the p62/Keap1/NRF2 pathway, demonstrating potentials as a therapeutic agent for HCC."
Journal • Hepatocellular Cancer • Oncology • Solid Tumor • FTH1 • GPX4 • SLC40A1
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Bin Wen; Binglian Zhong; Chunyu He; Haitao Sun; Songqi He; Weicong Chen; Weiguang Chen; Xuemei Yang; Yang Liu
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