WTX-L/β-arrestin2/LCN2 axis controls vulnerability to ferroptosis in gastric cancer. (PubMed, iScience) - Mar 20, 2025 - "Blockade of the WTX-L/β-arrestin2/NF-κB/LCN2 axis significantly diminished the activity of ferroptosis inducers (erastin and RSL3) in vivo. Collectively, these findings reveal that targeting the ferroptosis vulnerabilities through WTX-L may represent a promising strategy for GC."
Journal • Gastric Cancer • Oncology • Solid Tumor • ARRB1 • NFKBIA
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Chuangyuan Wang; Guixing Cai; Hongmei Wu; Jingbo Sun; Qingling Zhang; Weiye Huang; Xuexia Qian; Yangwei Xu; Yiqiong Zhang; Zhihao Lin
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