Monounsaturated fatty acids promote cancer radioresistance by inhibiting ferroptosis through ACSL3. (PubMed, Cell Death Dis) - Mar 19, 2025 - "Both OA and POA could protect cancer cells from the killing effects of the ferroptosis inducer erastin and RSL3, and OA had a stronger protective effect than POA, resulting in lower lipid ROS production than POA. A mouse model demonstrated that ACSL3 knockdown combined with imidazole ketone erastin synergistically enhanced antitumor effects in radiation-resistant tumors in vivo. Our study reveals previously undiscovered associations between radiation and fatty acid metabolism and ferroptosis, providing a novel treatment strategy for overcoming cancer radioresistance."
Journal • Oncology • ACSL3
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Bingxin Liu; Jiuming Li; Leyuan Zhou; Liuying Huang; Surui Yao; Ying Chen; Yuan Yin; Yuanben Wang; Yulin Cao; Yuyang Feng; Zhaohui Huang; Zhiang Liu
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