2-Aminomethyl phenothiazine, its alkyl and triphenylphosphonium derivatives suppress erastin-induced ferroptosis in BT-474 cells but exhibit distinct cytotoxic activities. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - Mar 5, 2025 - "In contrast, the alkyl derivative did not exhibit cytotoxic action up to a maximum concentration of 100 μM, which allows it to be recommended as a promising antiferroptotic agent with a wide therapeutic window. The current findings discuss the possible mechanisms of inhibitory action of the tested compounds on ferroptotic cell death."
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Anna I Ilzorkina; Anna Yu Spivak; Damiki Laloo; Darya A Nedopekina; Eldar V Davletshin; Jun Moni Kalita; Konstantin N Belosludtsev; Mikhail V Dubinin; Natalia V Belosludtseva; Natalia V Mikina; Rezeda R Khalitova
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