Determinants in Trimodality Therapy for Bladder Cancer: Overcoming Chemoradiotherapy Resistance via Ferroptosis (AUA 2025) - Mar 6, 2025 - Abstract #PD37-13; Pres time: Apr 29, 2025; 11:06 AM - 11:14 AM; Location: Marco Polo 805; In Person; "The combination of the ferroptosis inducer Erastin and irradiation overcame resistance in the T24R cell line, which is enriched with ferroptosis-suppressor genes (Figure 2C). Key survival determinants post-CRT were highlighted, positioning ferroptosis as a target for overcoming resistance (Figure 2D). Combining ferroptosis inducers with irradiation could offer a new therapeutic avenue for expanding bladder preservation."
Bladder Cancer • Genito-urinary Cancer • Metabolic Disorders • Oncology • Solid Tumor
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Takuya Tsujino; Shogo Yamazaki; Kazumasa Komura; Haruhito Azuma
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