FABP3 promotes cell apoptosis and oxidative stress by regulating ferroptosis in lens epithelial cells. (PubMed, Free Radic Res) - Mar 6, 2025 - "In addition, the inhibition of FABP3 knockdown on cell apoptosis, inflammation, and oxidative stress was reversed by ferroptosis inducer (erastin), and the promotion of FABP3 overexpression on cell apoptosis, inflammation, and oxidative stress was reversed by ferroptosis inhibitor (Fer-1). Taken together, knockdown of FABP3 in lens epithelial cells treated with H2O2 restrained apoptosis, inflammation, and oxidative stress through regulating ferroptosis, suggesting that FABP3 might be a potential target for cataract treatment."
IO biomarker • Journal • Cataract • Inflammation • Ophthalmology • BCL2 • CASP3 • FABP3 • GPX4 • IL1B • IL6 • SLC7A11 • TNFA
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Bin Yu; Chunxiao Zhang; Qi Wang; Yanyan Zhang; Yuanyuan Guo
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