Whole-cell Lysosome SMLM Imaging as Indicators for Functional Diagnostics with a Low-Phototoxic Spontaneously Blinking Probe. (PubMed, Angew Chem Int Ed Engl) - Feb 27, 2025 - "By analyzing these parameters, we investigated lysosomal function under acidosis and starvation and evaluated the effects of seven anticancer drugs (paclitaxel, rapamycin, periplocoside, metformin, erastin, polyphyllin and gefitinib). Notably, paclitaxel elevated lysosomal pH and led to a sparser lysosomal distribution. These findings underscore the potential of Aze-HMSiR as a powerful tool for diagnosing lysosomal function and monitoring dynamic changes in response to physiological conditions and pharmacological treatments, establishing it as a robust platform for functional diagnostics and drug screening, particularly in cancer therapy."
Journal • Metabolic Disorders • Oncology
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Aoxuan Song; Guanyu Jiang; Qinglong Qiao; Wenhao Jia; Xiaogang Liu; Yiyan Ruan; Yuxin Zhou; Zhaochao Xu
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