Osteosarcoma Cells and Undifferentiated Human Mesenchymal Stromal Cells Are More Susceptible to Ferroptosis than Differentiated Human Mesenchymal Stromal Cells. (PubMed, Antioxidants (Basel)) - Feb 26, 2025 - "Ferroptosis was induced by either inhibiting glutathione peroxidase 4 (GPX4) using RSL3 or blocking all glutathione-dependent enzymes through inhibition of the glutamate/cysteine antiporter with Erastin. Our data suggest that ferroptosis induction in undifferentiated hBMSCs is primarily regulated by GPX4, whereas glutathione S-Transferase P1 (GSTP1) plays a key role in controlling ferroptosis in osteosarcoma cells. In conclusion, targeting the key pathways involved in ferroptosis across different bone cell types may improve the efficacy of cancer treatments while minimizing collateral damage and supporting regenerative processes, with minimal impact on cancer therapy."
Journal • Oncology • Osteoporosis • Osteosarcoma • Rheumatology • Sarcoma • Solid Tumor • GPX4 • GSTP1
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Andreas Sebastian Gasser; Andrey V Kozlov; Annette Vaglio-Garro; Darja Marolt Presen; Dominik Hanetseder; Johanna Catharina Duvigneau; Lukas Derigo; Olga S Korneeva; Regina Brunauer; Simon Sperger; Yuliya D Smirnova
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