Polydatin and Nicotinamide Prevent Iron Accumulation and Lipid Peroxidation in Cellular Models of Mitochondrial Diseases. (PubMed, Antioxidants (Basel)) - Feb 26, 2025 - "Mutant fibroblasts showed increased iron and lipofuscin accumulation, altered expression of iron metabolism-related proteins, elevated lipid peroxidation, and heightened susceptibility to erastin-induced ferroptosis...Notably, adding vitamin E to the polydatin and nicotinamide co-treatment resulted in a reduction in the minimum effective concentration, suggesting potential benefits of its inclusion. In conclusion, the combination of polydatin, nicotinamide, and vitamin E could represent a promising therapeutic option for patients with mitochondrial disorders caused by pathogenic GFM1 variants."
Journal • Metabolic Disorders • GFM1
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Alejandra López-Cabrera; Ana Romero-González; Andrés Rodríguez-Sacristan; David Gómez-Fernandez; Diana Reche-López; José Antonio Sánchez-Alcazar; José Manuel García-Verdugo; Jose Manuel Romero-Domínguez; Marta Castro De Oliveira; Mónica Álvarez-Córdoba; Paula Cilleros-Holgado; Rocío Piñero-Perez; Susana González-Granero
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