Study on the mechanism of Wnt/β-catenin pathway mediated by pterostilbene to reduce cerebral ischemia-reperfusion injury. (PubMed, Biomol Biomed) - Feb 20, 2025 - "Treatments included PTE, the ferroptosis activator Erastin, and the Wnt signaling pathway inhibitor (Dkk-1)...Specifically, PTE upregulated the Wnt/β-catenin pathway, decreased peroxide accumulation, and antagonized ferroptosis, ultimately mitigating CIRI. These findings suggest that PTE protects against CIRI by modulating the Wnt/β-catenin pathway and alleviating ferroptosis-induced damage."
Journal • Cardiovascular • CNS Disorders • Ischemic stroke • Reperfusion Injury • DKK1 • GPX4
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Chunwang Fu; Ming Guo; Qiang Yang; Yang Jin
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