The Role of DDX10 in Hepatocellular Carcinoma Metastasis: Regulation of Ferroptosis (APASL 2025) - Feb 20, 2025 - Abstract #PP1041; Pres time: Mar 29, 2025; 09:00 AM - 05:00 PM; "Notably, DDX10 reversed Erastin-induced ferroptosis suppression of cell migration and invasion... Our findings establish a novel DDX10/SIRT7/NCOA4 axis critical for ferroptosis regulation and HCC metastasis. These results highlight DDX10 as a potential biomarker and therapeutic target for metastatic HCC. Future studies will explore the molecular mechanisms underlying the DDX10-SIRT7 interaction and its translational applications in HCC treatment."
Hepatocellular Cancer • Oncology • Solid Tumor • DDX1 • DDX10 • NCOA4 • SIRT7
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Mingyu Zhang 1; Jiazhi Liao 1; Suhong Xia 1
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