Study on the active components of Fuzheng Huayu formal and their anti-fibrotic mechanisms (APASL 2025) - Feb 20, 2025 - Abstract #PP0775; Pres time: Mar 29, 2025; 09:00 AM - 05:00 PM; "We further found that Sal B significantly attenuated liver fibrosis in carbon tetrachloride (CCl4)-induced mice, and suppressed erastin- or CCl4-induced hepatocyte ferroptosis in vitro. Sal B, amygdalin, Sin A and C02 are the main ingredients of FZHY against liver fibrosis through protecting hepatocyte from damage, anti-hepatic sinusoidal endothelial cell injury, inhibition of inflammatory response and activation of hepatic stellate cells separately. In addition, ECM1, CDK9, PPARα and cGAS/Sting are the key targets of these ingredients."
Fibrosis • Hepatology • Immunology • Inflammation • Liver Cirrhosis • Metabolic Disorders • Metabolic Dysfunction-Associated Steatohepatitis • ABCB4 • CDK9 • PPARA • SLC7A11
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Jiamei Chen 1, 2; Wei Liu 1, 2; Ping Liu 1, 2, 3
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