Mechanism of sodium valproate in inhibiting ferroptosis of bone marrow mesenchymal stem cells via the adenosine monophosphate-activated protein kinase/Sirtuin 1 axis

erastin - Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Columbia University, Prolexys

selisistat (SEN-196) - AOP Orphan Pharma

sodium valproate - Generic mfg.

Mechanism of sodium valproate in inhibiting ferroptosis of bone marrow mesenchymal stem cells via the adenosine monophosphate-activated protein kinase/Sirtuin 1 axis (PubMed, Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi) - Feb 20, 2025 - "To investigate the effects of sodium valproate (VPA) in inhibiting Erastin-induced ferroptosis in bone marrow mesenchymal stem cells (BMSCs) and its underlying mechanisms. These effects could be reversed by the SIRT1 inhibitor EX527. VPA inhibits ferroptosis in BMSCs through the AMPK/SIRT1 axis and promotes osteogenesis."
Journal • Osteoporosis • Rheumatology • GPX4 • PTPRC • RUNX2 • SIRT1 • SLC7A11 • SPP1 • THY1

http://www.ncbi.nlm.nih.gov/pubmed/39971368

Jianqiao Li; Linhui Wang; Min Yang; Qingsong Gu; Yicong Wang; Yiheng Li; Yuhu Chen; Ziru Wang

Feb 20, 2025