Macrophages hijack carbapenem-resistance hypervirulent Klebsiella pneumoniae by blocking SLC7A11/GSH-manipulated iron oxidative stress. (PubMed, Free Radic Biol Med) - Feb 19, 2025 - "Treatment with the ferroptosis agonist Erastin or Sorafenib decreased the SLC7A11 expression and the bacterial load in infected lung tissues, alleviating CR-hvKP-induced acute lung injury, increasing the content of TLR4, ROS and LPO. Mechanically, blocking the expression of SLC7A11 in CR-hvKP-infected MH-S cells increased iron and ROS, improving the ability of macrophages to clear CR-hvKP in an LPO-dependent manner. Taken together, our study reveals that improving iron-related oxygen stress via blocking the SLC7A11/GSH pathway promoting the macrophages to phagocytose and eliminate CR-hvKP, which provides a new promising strategy against CR-hvKP infection."
Journal • Acute Lung Injury • Infectious Disease • Pneumonia • Respiratory Diseases • SLC7A11 • TLR4
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Beiwen Zheng; Gensheng Zhang; Heyu Chen; Jiachang Cai; Jie Yang; Peng Guo; Qing Yu; Ruishan Liu; Ruomeng Hu; Shikuan Yang; Shufang Zhang; Zhijian Cai
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