Targeted ErbB4 receptor activation prevents D-galactose-induced neuronal senescence via inhibiting ferroptosis pathway. (PubMed, Front Pharmacol) - Feb 17, 2025 - "Additionally, E4A markedly ameliorated Erastin-induced ferroptosis in mouse hippocampal neuronal cells. Our findings suggest that targeted activation of ErbB4 receptor may be a viable strategy for treating neuronal senescence by inhibiting ferroptosis, thereby offering a potential therapeutic avenue for senescence-associated neurodegenerative diseases."
Journal • CNS Disorders • CDKN1A • ERBB4 • GFAP • LMNB1
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Chen-Meng Qiao; Chong Liu; Chun Cui; Ji-Ji Dao; Qian Li; Shuang-Xi Chen; Wei Zhang; Wei-Jiang Zhao; Yan-Qin Shen
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