Adiponectin ameliorates traumatic brain injury-induced ferroptosis through AMPK- ACC1 signaling pathway. (PubMed, Brain Behav Immun) - Feb 14, 2025 - "Furthermore, AdipoR1 knockdown significantly diminished the protective effects of AdipoRon against erastin-induced ferroptosis in primary neurons...Mechanically, activation of APN-AdipoR1 signaling promoted adenosine monophosphate activated protein kinase (AMPK) -mediated phosphorylation of acetyl-CoA carboxylase-1 (ACC1), thus suppressed the PUFAs biosynthesis, which determines theferroptosissensitivity of neurons. Taken together, these findings provided compelling evidence for the protective role of APN-AdipoR1 signaling against TBI-induced ferroptosis by inhibiting AMPK-ACC1."
Journal • CNS Disorders • Vascular Neurology • ACACA • AMPK
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Bodong Wang; Dayun Feng; Haixiao Liu; Hao Guo; Jin Wang; Qing Hu; Shenghao Zhang; Shunnan Ge; Tian Feng; Tinghao Wang; Wendong Xie; Xun Wu; Yan Qu; Yaning Cai; Yufeng Ge
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