Quercetin inhibits oligodendrocytes ferroptosis by blocking NCOA4-mediated ferritinophagy. (PubMed, Int Immunopharmacol) - Feb 14, 2025 - "Compared with the erastin and quercetin treated OPCs, increased rerrous iron, lipid peroxidation production, and decreased GSH content, as well as shrunken mitochondria, were observed in OPCs treated with a combination of erastin, quercetin, and rapamycin. In conclusion, our findings revealed that quercetin inhibits OPCs ferroptosis by blocking NCOA4-mediated ferritinophagy. Quercetin and ferritinophagy may be potential therapeutic agents for SCI."
Journal • CNS Disorders • Orthopedics • Solid Tumor • NCOA4 • PACERR • PTGS2 • SQSTM1
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Hongdong Chen; Kaifan Li; Lei Yang; Man Xiong; Mingsen Wang; Sidong Luo; Wei Wei; Xinfang Liu; Xu Wang; Yeyang Wang; Yongsheng Li
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