Lycium barbarum glycopeptide reduces brain damage following ischemic stroke by inhibiting ferroptosis and oxidation. (PubMed, Neural Regen Res) - Feb 11, 2025 - "Liproxstatin-1, a ferroptosis inhibitor, and Erastin, a ferroptosis activator, were used as controls. Therefore, the positive effects of Lycium barbarum glycopeptide in ischemic stroke are likely mediated through activation of the anti-ferroptotic pathway and the antioxidative System Xc-glutathione-glutathione peroxidase 4 pathway. Overall, our findings highlight the potential use of Lycium barbarum glycopeptide as a neuroprotective agent targeting both ferroptosis and oxidation to decrease ischemic brain damage."
Journal • Cardiovascular • CNS Disorders • Depression • Hematological Disorders • Ischemic stroke • Mood Disorders • Psychiatry • Vascular Neurology • ACSL4 • GPX4 • SLC7A11
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Jian Wang; Kwok-Fai So; Lihui Zhu; Moushen Tang; Wei Zhang; Yiwen Ruan; Yongxia Huang; Yujie Wang; Zhexiong Yu
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