Rab7-regulated ferroptosis contributes to tubular epithelial cells injury by degradation of GPX4 via chaperone-mediated autophagy in AKI. (PubMed, Am J Physiol Cell Physiol) - Feb 11, 2025 - "The injury and ferroptosis were observed following the administration of erastin or ferrostatin-1 (Fer-1), as well as the downregulation of Rab7...Finally, we assessed the injury and ferroptosis after the combination of RAS-selective lethal 3 (RSL3) and downregulation of Rab7...Ferroptosis is important in TEC injury during AKI and Rab7 promotes tubular ferroptosis by facilitating CMA-mediated degradation of GPX4.NEW & NOTEWORTHY To explore the mechanism underlying ferroptosis in I/R-induced renal injury and to confirm the effect of Rab7, we first evaluated ferroptosis in renal biopsy samples, and then examined Rab7 expression and renal tubular injury during AKI in vivo and in vitro. Finally, we performed in vitro experiments to investigate the specific role of Rab7 in the regulation of ferroptosis and showed that the regulatory mechanism was related to CMA-mediated GPX4 degradation in renal TECs."
Journal • Acute Kidney Injury • Cardiovascular • Nephrology • Renal Disease • Reperfusion Injury • FER • GPX4 • HIF1A
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Hui Sun; Lei Liu; Lijuan Tang; Qishuang Wei; Renyu Wang; Shali Yu; Shuang Zhang; Sijing He; Yifei Liu
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