4-Hydroxyestrogen Metabolites Strongly Prevent Chemically-Induced Ferroptotic Hepatocyte Injury In Vitro and In Vivo. (PubMed, Eur J Pharmacol) - Feb 8, 2025 - "The induction of ferroptotic cell death by erastin and RSL3 in rat H-4-II-E and human HuH-7 hepatoma cells is used as in vitro models. In vivo animal studies show that 4-OH-E1 and 4-OH-E2 also have a strong protective effect against acetaminophen-induced liver injury in a mouse model. Together, the results of this study demonstrate that 4-OH-E1 and 4-OH-E2 are endogenous factors with a strong protective activity against chemically-induced hepatocyte injury both in vitro and in vivo."
Journal • Preclinical • Hepatocellular Cancer • Hepatology • Liver Cancer • Liver Failure • Solid Tumor
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Bao Ting Zhu; Qi Zhang; Xi Sun; Xiangyu Hao; Yan-Yin Zhu; Yi-Chen Jia; Yong Xiao Yang
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