4-octyl Itaconate Attenuates Acute Pancreatitis and Associated Lung Injury by Suppressing Ferroptosis in Mice. (PubMed, Inflammation) - Feb 8, 2025 - "The ferroptosis activator Erastin blocked the protective effect of 4-OI against pancreatic injury in AP, validating that 4-OI alleviates pancreatitis injury through ferroptosis. In vitro experiments further confirmed that 4-OI treatment ameliorated AP-induced pancreatic injury by inhibiting ferroptosis. Our study, for the first time, found that 4-OI ameliorates AP and AP-related lung injury by inhibiting ferroptosis in experimental AP mice, providing a new therapeutic target for alleviating AP."
Journal • Preclinical • Gastrointestinal Disorder • Hepatology • Inflammation • Pancreatitis • Respiratory Diseases
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Mingming Qi; Pengzhan He; Shimin Lu; Weiguo Dong; Yang Gong
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